1. Isoelectric point of polypeptide:(1) is pH at which the o-carboxyl and o-amino groups are uncharged.(2) is pH at which the net charge on the molecules in solution is 0.(3) is pH at which the charge of the o-carboxyl group is higher than the charge of the o-amino group.А. (1) onlyВ. (2) onlyС. (3) onlyD. (1) and (3)E. (2) and(3)

Proteins are polymers made of monomers called amino acids, mostly L-amino acids. There are different…

Answered: 1. Isoelectric point of polypeptide:…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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a) Draw a non-covalent interaction between a water molecule and the charge on a phosphorylated serine residue(not including backbone atoms). What type of interactuon is this, how strong is it, and what holds the interaction together? b)Draw a non-covalent interaction between an alanine residue and a valine residue(not including backbone atoms). What type of interaction is this, how strong is it, and what holds the interaction together?
Label: 1) the type of chemical bonds between the amino acids (e.g. covalent bond, ionic bond, metallic bond) 2) the type of interparticle forces of attraction occurring within the protein and with its environment *Indicate at least four observed interparticle forces of attraction *pink - negatively charged, blue - positively charged, yellow - nonpolar and uncharged, green - polar and uncharged *[See example picture] The chemical bond (shown by the arrow) is depicted as a line between the amino acids. Interparticle forces of attraction, such as the one between Phe and Glu (boxed), are not represented by lines but rather by the proximity of amino acids.
The pH vs charge graph for a triprotic amino acid is shown below. Please answer the following questions about the amino acid. Net Charge 0 2 4 Alpha amino [Select] 6 R [Select] pH a. Which of the following triprotic amino acids is this? Alpha carboxyl [Select] 8 10 12 [ Select] 14 1 0.5 0 -0.5 -1 b. What is the isoelectric point? (Please select the appropriate range in which the isoelectric point falls) (Hint - look up the pKa values in the pKa table for amino acids, which was in video one of today's lecture) [Select] -1.5 c. What form of this amino acid dominates at a pH of 14? Please select the correct form for each ionizable group. -2
1. Draw the peptide chain (indicate if it is solid or hatched wedges) for the following and compute for the isoelectric point. Show solution. Glycine-(L)-Arginine-(D)-Proline-(L)-Glutamic Acid
The pH vs charge graph for a triprotic amino acid is shown below. Please answer the following questions about the amino acid. 2 1.5 1 0.5 -0.5 -1 4 6. 8 10 12 14 pH a. Which of the following triprotic amino acids is this? [ Select ] b. What is the isoelectric point? (Please select the appropriate range in which the isoelectric point falls) (Hint - look up the pka values in the pKa table for amino acids, which was in video one of today's lecture) [ Select ] c. What form of this amino acid dominates at a pH of 8? Please select the correct form for each ionizable group. Alpha amino [ Select ] Alpha carboxyl [ Select ] R [ Select ] Net Charge
8. A dipeptide T, obtained from the breakdown of an enzyme found in the human body, is made up of Amino Acids R and S. (a) Classify Amino Acids R and S as an acidic amino acid or a basic amino acid. (b) Name Bond Q. (c) State any ONE type of protein that could be found in human body. (2%) (1%) (1%)
Currently, aspartic acid is forming an ionic interaction with arginine in a protein. Part a) If arginine is replaced with glutamic acid, would the ionic interaction have its stability increased, decreased, or have no effect on the ionic interaction? Part b) If arginine is replaced with Lysine, would the ionic interaction have its stability increased, decreased, or have no effect on the ionic interaction? Part c) If arginine is replaced with isoleucine, would the ionic interaction have its stability increased, decreased, or have no effect on the ionic interaction?
What charged groups are present in lysine at a pH = 7? O A) 1 × NH3¹ B) 1 x COO OC) 1× NH3+ and 1 x COO- Jay OD) 2 × NH3 and 1 × COO- + OE) 1 × NH3+ and 2 × COO- O F) None
1. Since the pK values for aspartic acid are 2.0, 3.9 and 10.0, it follows that the isoelectric (pH) is (A) 3.0 (B) 3.9 (C) 5.9 (D) 6.0
2) What is glycoside ? In neutral and basic solutions, glycosides do not show mutarotation. However, if the solutions are made acidic, glycosides show mutarotation. Explain why? And write a mutarotation mechanism.
1. What is the isoelectric point (pI) of lysine which has pKa values of 2.1 for the α carboxyl group, 9.7 for the α amino group and 10.5 for the side chain amino group? 2. Which of the following is most likely to be found on the exterior of a protein? A) Pro B) Trp C) Ser D) Glu 3. The type of reaction that forms a peptide bond is A) Elimination B) Hydrolysis C) Nucleophilic substitution D) Condensation
Indicate which of the amino acid residues in the following peptide sequence contains a group that has a positive charge for its most likely charge state at pH 10. Asp-Tyr-Lys-GIn-Thr-Ile-Phe-Met-Ser (If none of the amino acids fit the criterion, select "none".) Asp Tyr ооооооооо Lys Gln Thr lle Phe Met Ser none

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