A particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerize

A particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerize

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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Glucocorticoids are sterojd hormones that are released into the circulation and will cause changes to gene expression in the cells that respond. Which of the following would be a factor that can determine whether a cell will respond to circulating glucocorticoids? Whether the cell expresses the lac repressor. O A. O B. Whether the cell expresses the CREB protein. Whether the cell expresses the glucocorticoid receptor. C. Whether CAMP is produced at high levels by adenylyl cyclase. D. O E. Whether adenylyl cyclase is activated or not.
G protein coupled receptors play an important role in signal transduction in many cells. Label the four essential components of the G protein coupled receptor signaling system (blanks a-d in the picture) by choosing from the menus below. a b b Each answer will be used at most once, while some will not be used at all (select one for each): Group of answer choices transcription factor с transcription factor Show Transcribed Text d transcription factor B C. transcription factor G protein second messenger G protein second messenger IE G protein second messenger G protein second messenger receptor receptor receptor receptor enzyme enzyme enzyme enzyme steroid hormone steroid hormone steroid hormone steroid hormone
Which of the following is NOT an example of allosteric regulation? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Phosphorylation of the CTD of RNA polymerase II. b с d Lactose binding to the Repressor protein. GTP binding to elF2. CAMP binding to cAMP protein-dependent kinase
which of the following correctly describes how protein kinase A can activate genes? A: nuclear protein kinase A is activated by cAMP to phosphorylate general transcription factors B: cytosolic protein kinase A is activated by cAMP to release the catalytic subunits, which move into the nucleus and phosphorylate CREB C: cytosolic protein kinase A is activated by cAMP to release the catalytic subunits, which move into the nucleus and phosphorylate general transcription factors D: G protein-coupled receptors may be desensitized by serine phosphorylation
The figure below shows how normal signaling works with a Ras protein acting downstream of a receptor tyrosine kinase. CYTOSOL active receptor tyrosine kinase Taratas THERI signal molecule 00 active signaling Q Search active Ras protein GTP 99+ Į SIGNALING Il app.honorlock.com is sharing your screen. ✡ active signaling protein Y a
When glucose is low and CAMP is present, CAMP's role is to O Activate catabolite activator protein (CAP) Activate RNA Polymerase Activate the repressor Deactivate the repressor
Serotonin is a neurotransmitter that is a small, soluble molecule. P11 (a small protein) is required for transport of serotonin receptors to the cell surface. Assume for this problem that p11 affects transport of serotonin receptors only, and that it does not affect transport of any other proteins (a simplification). Depressed people seem to have low levels of p11; treatments that improve mood increase the expression of the p11 gene. NSAIDs (aspirin, ibuprofen, etc.) seem to decrease expression of p11. SSRIs (selective serotonin reuptake inhibitors) decrease re-uptake of serotonin at synapses. Some depressed patients are helped by SSRIs, but some are not. Explain both parts of B. B-1. The results indicate that depression can be caused by levels of serotonin receptors that are (higher than normal) (lower than normal) (neither – no evidence here for any effect on depression) (higher or lower but can't tell which). B-2. If a depressed person does not respond to SSRIs, the person…
Binding of a ligand (like TGFA) to a receptor tyrosine kinase (RTK) causes all of the following except (can use cell): OA. Dimerization of the receptor B. Auto-phosphorylation of the receptor O C. Activation of Ras through an interction with GRB2 (an adaptor) and SOS (a GEF) proteins. O D. Activation of heterotrimeric G proteins
If a cell expresses a dominant-negative tyrosine-kinase-linked receptor (RTK) that lacks the kinase domain, which of the following will still happen in response to a growth factor that binds the RTK? A Receptor cross-phosphorylation. Activation of target proteins by Ras. C) Receptor dimerization. D) Binding of the growth factor to its receptor. Interaction of Ras with the activated receptor. B
Phorbol esters have been observed to induce the transcription of AP-1–influenced genes. Explain how this processcould occur. What are the consequences of AP-1 transcription? What role does intermittent exposure to phorbol estershave on an individual’s health?
a.What would happen if IKKbeta did not phosphorylate IkappaB? b.Why is it so hard to make cytokine therapies? c.Why would you use the MyD88 independent pathway versus the MyD88 dependent pathway?
Discuss the family of nuclear hormone receptors and explain how ligand binding to such a receptor can result in changes in gene expression