Arsenate (AsO43− ), a structural analog of phosphate, can act as a substrate for any reaction in which phosphate is a substrate. Arsenate esters, unlike phosphate esters, are kinetically as well as thermodynamically unstable and hydrolyze almost instantaneously. Write a balanced overall equation for the conversion of glucose to pyruvate in the presence of ATP, ADP, NAD+, and either (a) phosphate or (b) arsenate. (c) Why is arsenate a poison?

Arsenate (AsO43− ), a structural analog of phosphate, can act as a substrate for any reaction in which phosphate is a substrate. Arsenate esters, unlike phosphate esters, are kinetically as well as thermodynamically unstable and hydrolyze almost instantaneously. Write a balanced overall equation for the conversion of glucose to pyruvate in the presence of ATP, ADP, NAD+, and either (a) phosphate or (b) arsenate. (c) Why is arsenate a poison?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter25: Nitrogen Acquisition And Amino Acid Metabolism

Section: Chapter Questions

Problem 22P

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