Lactate dehydrogenase (LDH) plays an essential role in an exercising muscle, especially when the level of excursion surpasses the ability of circulatory systems ability to supply adequate oxygen. What is the main reason LDH is so important to the muscle under these conditions? It produces one mole of ATP via substrate level phosphorylation It resupplies NAD+ to glyceraldehyde 3-phosphate dehydrogenase. It decreases pH thus decreasing the dissociation rate of oxygen from hemoglobin It produces NADH for energy while converting pyruvate into lactate. It removes excess lactic acid from the muscle to create pyruvate. Next

Lactate dehydrogenase (LDH) plays an essential role in an exercising muscle, especially when the level of excursion surpasses the ability of circulatory systems ability to supply adequate oxygen. What is the main reason LDH is so important to the muscle under these conditions? It produces one mole of ATP via substrate level phosphorylation It resupplies NAD+ to glyceraldehyde 3-phosphate dehydrogenase. It decreases pH thus decreasing the dissociation rate of oxygen from hemoglobin It produces NADH for energy while converting pyruvate into lactate. It removes excess lactic acid from the muscle to create pyruvate. Next

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Assuming that the glycerol 3-phosphate shuttle is operative, a complete oxidation of three molecules of glucose (by a eukaryotic cell) into carbon dioxide and water would produce approximately ATP molecules via oxidative phosphorylation only. (Consider NADH = 2.5 ATP and FADH2 = 1.5 ATP)
Arsenate can replace inorganic phosphate in the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase, causing glyceraldehyde-3-phosphate to be directly converted to 3-phosphoglycerate(NADH is still formed). Which of the following is absolutely true in case of arsenate poisoning -Glycolysis will stop - Glycolysis will still proceed with no net ATP gain - Glycolysis will not generate any form of energy - Glycolysis will still proceed, but with a net consumption of ATP - Glycolysis will proceed with lactate as end product
The conversion of glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate reduces NAD+ to NADH. Under anaerobic conditions, how is NADH oxidized back to allow for continuing glycolysis? (name the compounds involved in the reaction besides NADH and their draw structures)
Which of the following is higher during high levels of glutathione reductase and NADP? SH A но (GSH) OH NH2 NH2 HO OH ;-CH-CH2-CH2-C-NH-CH–ċ–NH–CH2- CH2 В (GSSG) CH2 -CH-CH;-CH2=C-NH–C NH-CH–Ç-NH-CH2-C HO OH NH2
During periods of intense physical exercise, the demand for ATP in muscle tissue increases dramatically. L-lactic acid fermentation accounts for almost all of the ATP production in rabbit leg muscle and turkey flight muscle, respectively. A pair of processes, phosphoglycerate kinase and pyruvate kinase, are involved in the formation of ATP during the payout phase of glycolysis. Assume that the enzyme lactate dehydrogenase is absent from skeletal muscle. Could it withstand rigorous physical activity, that is, could it create large amounts of ATP at a rapid pace via the process of glycolysis? Explain.
Assuming all the NADH+H+ and FADH2 are used for oxidative phosphorylation, how many net ATP are made from 1 molecule of glucose? (hint: don’t forget to also include substrate level phosphorylation)
A specialized lysine-linked co-enzyme often participates in the transfer of carbon fragments within an enzyme complex. Which group of three enzymes below make use of lysine-linked co-enztmes. Pyruvate dehydrogenase complex, a-Ketoglutarate dehydrogenase complex, NADH-Q oxidoreductase Pyruvate dehydrogenase complex, Succinate-Q oxidoreductase, Pyruvate carboxylase Pyruvate dehydrogenase complex, a-Ketoglutarate dehydrogenase complex, Pyruvate carboxylase Pyruvate dehydrogenase complex, Succinate-Q oxidoreductase, NADH-Qoxidoreductase Coordinate regulation occurs when different metabolic pathways are impact by a common compound. Which molecules below are compounds of coordinated regulation? Acety-CoA Molecular oxygen ATP NADH
I'm confused about glycolysis and gluconeogenesis. Question: What is the function of glyceraldehyde 3-phosphate dehydrogenase in gluconeogenesis? Would the answer be -> Oxidation of NADH and release of an ADP from glyceraldehyde 3-phosphate or -> Oxidation of NADH and release of phosphate from glyceraldehyde 3-phosphate or -> Oxidation of NADH and release of phosphate from 1,3 bisphosphoglycerate
The transformation of glucose to lactate in myocytes releases only about 7% of the free energy released when glucose is completely oxidized to CO2 and H2O. Does this mean that anaerobic glycolysis in muscle is a wasteful use of glucose? Explain.
Which of the following conditions is most likely to force a muscle cell to metabolize glucose anaerobically(fermentation) under normal oxygenation ? - Glyceraldehyde-3-phosphate dehydrogenase deficiency - Lactate dehydrogenase deficiency -Pyruvate kinase deficiency -Aldolase deficiency - Cytososic Glycerol-3-phosphate dehydrogenase deficiency
Under anaerobic conditions, pyruvate will be converted to lactic acid. Why does this occur? To convert NADH to NAD* to feed back into glycolysis To supply the glycolysis reaction glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate with needed electrons in the form of NADH Because lactic acid can be converted to glucose to feed back into glycolysis Because lactic acid is needed to resupply glycolysis with electrons O
The glycolytic enzymes hexokinase and glucokinase (in human liver cells) catalyze the conversion of: 1,3-bisphosphoglycerate into 3-phosphoglycerate (producing ATP) glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate (producing NADH) phosphoenolpyruvate into pyruvate (producing ATP) fructose-6-phosphate into fructose-1,6-bisphosphate (consuming ATP) glucose into glucose-6-phosphate (consuming ATP) Which of the following glycolytic enzymes must consume ATP during phosphorylation of its preferred substrate molecule? phosphoglycerate mutase succinate dehydrogenase phosphoglycerate kinase phosphofructokinase pyruvate kinase