signaling molecule from the ZPA?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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what experiemnts show Shh is the signaling molecule from the ZPA?

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The SHH gene provides instructions for making a protein called Sonic Hedgehog.

  • This protein functions as a chemical signal that is essential for embryonic development.
  • Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping of the body.

Signals that instruct the developing limb bud mesenchyme to form the appropriate elements along the anterior posterior axis emanate from the zone of polarizing activity (ZPA). Sonic hedgehog (Shh) protein mediates the activities of the ZPA.

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