What is the genetic phenomenon by which, two individuals carrying the same allele causing a disease do not express the same symptoms (phenotype)? Use the editor to format your answer I
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- A woman diagnosed with early-onset Alzheimer's due to a mutation of the APP genehas children with a man that has no family history of familial Alzheimer's. Give the probability of each possible genotype with corresponding phenotype. (The woman has two possible allele combinations. You must show both possibilities)In man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?Duchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?
- Huntington's disease is a very rare, debilitating disease that affects approximately 1 in 10,000 people. The disease is caused by a particular type of genetic mutation (large number of CAG repeats) in a gene called huntingtin (HTT). Designate the disease-causing allele HTTP and the non-disease- causing allele HTTN. We know that individuals with genotype HTTN will not develop Huntington's Disease, but people with either HTTD/HTTP or HTTN/HTTD will develop the disease. Which allele is dominant--HTTN or HTTP? Explain your reasoning thoroughly, using the correct definition of dominance.Give typing answer with explanation and conclusion The father of Mr Spock, first officer of the starship Enterprise, came from planet Vulcan; Spock’s mother came from Earth. A Vulcan has pointed ears (P), adrenals absent (A), and a right-sided double heart (R). All these alleles are dominant to Earth alleles. The three loci are autosomal, and they are linked as shown: --P----- 15 mu -----A-------- 20 mu --------R— Here's the new twist: having Vulcan adrenals and a human heart is an embryonic lethal combination, which will distort the proportion of the various phenotypes. If Mr Spock marries an Earth woman and there is no genetic interference, what proportion (0…1.0) of their children will have the phenotypes: A. Human ears, Vulcan heart, human adrenals B. Human ears, human heart, Vulcan adrenals C. Vulcan ears, Vulcan heart, Vulcan adrenals D. Vulcan ears, human heart, human adrenalsCystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f What is the genotype of individual #13? A) ff B) FF C) Ff D) it is impossible to tell
- In the DNA, different alleles of a gene have a different sequence of ***18. Complete this flowchart to show how different alleles can result in different characteristics. different sequence of in transcription > different sequence of in a protein translation > different structure and function of the protein (e.g. normal enzyme vs. defective enzyme) > different characteristics (e.g. normal color vs. albino) In this section, you will analyze how different alleles of the hemoglobin gene can result in sickle cell ar vs. normal health. ***19. Compare the nucleotide sequence in the "Beginning of Normal Hemoglobin Gene" vs. the "Beginning of Sickle Cell Hemoglobin Gene". What is the only difference?Sickle cell anemia causes hemoglobin, the oxygen - carrying molecule of red blood cells, to be misshapen resulting in disease. "H" is the normal hemoglobin allele and "h" is the allele for sickle - cell shaped hemoglobin. In order to get the disease, a person must have a recessive genotype (hh). Two people with normal red blood cells are carriers of the gene - they have m genotypes Hh. Questions: a. What are the possible genotypes of the eggs the woman can produce? b. What are the possible genotypes of the sperm the man can produce? c. What is the genotypic ration for the offspring? d. What is the phenotype ratio for the offspring? e. What is the couple's chance of having a child a sickle cell anemia?If an individual is diagnosed with multiple karyotypes, they are called? Choose from the options in the image.
- Duchenne’s muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness and is often fatal. “XD” represents the wild type allele, and “Xd,” the mutant allele. Jonah is XDXd Y and his brother Pete is Xd Y. Jonah and Pete BOTH have DMD of equal severity and phenotypes. You might have thought Jonah’s DMD would be less severe given his genotype. To better understand the situation, you investigate Jonah’s Xist chromosome region in his defective muscle cells. Which of the following is consistent with his phenotype? (Select all that apply.) The Xd-containing chromosome is inactive in defective muscle cells. The XD-containing chromosome has a methylated Xist promoter. The XD-containing chromosome has an unmethylated Xist promoter. The Xd-containing chromosome is active in defective muscle cells.Explain how differences in alleles can result in different phenotypes. Be sure to include a specific example in your answer. Give typed full explanationExplain at the biochemical or enzymatic level, the phenotypic consequencesof alleles incase of following cross. Rr (pink flower) x Rr (pink flower) (progeny are 1 RR (red flower) :2 Rr (pink flower): 1rr(white flower) how alleles contribute to a phenotype through metabolism.